PATHOLOGY

Detailed explanation-1: -Platelets are formed from the cytoplasm of megakaryocytes (MKs), their precursor cells, which reside in the bone marrow (Pease, 1956).

Detailed explanation-2: -Megakaryocytes are hematopoietic cells, which are responsible for the production of blood platelets. The traditional view of megakaryopoiesis describes the cellular journey from hematopoietic stem cells, through a hierarchical series of progenitor cells, ultimately to a mature megakaryocyte.

Detailed explanation-3: -Megakaryocytes are bone marrow platelet progenitors, which undergo endomitosis rather than mitosis and cell division. Megakaryocytes are extremely large cells (generally 50 to 150 µm), which have a single nucleus with multiple lobes (2–16).