PATHOLOGY MCQ
HAEMOPOIETIC SYSTEM
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Question
[CLICK ON ANY CHOICE TO KNOW THE RIGHT ANSWER]
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It is believed to represent approximately 1% of bone marrow cells.
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It is thought to have a CD34+ and CD38-phenotype.
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It resembles a small to medium sized lymphocyte.
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It is effectively transferred during stem cell transplantation.
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Detailed explanation-1: -CD34 is routinely used to identify and isolate human hematopoietic stem/progenitor cells (HSPCs) for use clinically in bone marrow transplantation, but its function on these cells remains elusive.
Detailed explanation-2: -Hematopoietic stem cells (HSC) possess multipotentiality, enabling them to self-renew and also to produce mature blood cells, such as erythrocytes, leukocytes, platelets, and lymphocytes. CD34 is a marker of human HSC, and all colony-forming activity of human bone marrow (BM) cells is found in the CD34+ fraction.
Detailed explanation-3: -(hee-MA-toh-poy-EH-tik stem sel) An immature cell that can develop into all types of blood cells, including white blood cells, red blood cells, and platelets. Hematopoietic stem cells are found in the peripheral blood and the bone marrow. Also called blood stem cell.