PATHOLOGY

Detailed explanation-1: -The most common cause of acquired bone marrow failure is aplastic anemia. (See Etiology, Presentation, Workup, and Treatment.) Diseases that can present in a manner similar to acquired bone marrow failure include myelodysplastic syndromes, paroxysmal nocturnal hemoglobinuria, and large granular lymphocytic leukemia.

Detailed explanation-2: -When the bone marrow’s hematopoietic stem cells are damaged, the body cannot make enough red, white, or platelet blood cells. Insufficient red blood cell production causes anemia, which has low energy as its main symptom. Decreased white blood cells raise the risk of infections.

Detailed explanation-3: -The inherited bone marrow failure syndromes (IBMFS) are a group of rare genetic blood disorders in which there is usually some form of aplastic anemia (failure of the bone marrow to produce blood), associated with a family history of the same disorder.