PATHOLOGY

Detailed explanation-1: -The formation of collagen cross-links is attributable to the presence of two aldehyde-containing amino acids which react with other amino acids in collagen to generate difunctional, trifunctional, and tetrafunctional cross-links.

Detailed explanation-2: -In particular, the process of crosslinking not only improves the mechanical properties of a collagen scaffold but also results in further modifications to the molecular structure of collagen.

Detailed explanation-3: -The cross-linking theory of aging (also known as the glycosylation theory of aging) attributes aging to chemical changes that happen in the body. These changes happen gradually as proteins, structural molecules, and DNA develops detrimental chemical bonds (also known as cross-links) to each other.

Detailed explanation-4: -CXL is a relatively safe procedure with a low complication rate. A majority of CXL complications occur due to epithelial debridement.