PATHOLOGY

Detailed explanation-1: -Granulation tissue is an important component in the wound healing process. Wounds can heal by primary intention (wound edges approximate easily) and secondary intention (wounds edges do not approximate). Granulation tissue matrix will fill wounds that heal by second intention.

Detailed explanation-2: -Cells and proliferating capillaries are the two major components of granulation tissue. The cells are chiefly fibroblasts and inflammatory cells-macrophages, lymphocytes, plasma cells, and neutrophils depending on the stage and development of the granula-tion tissue and the presence of infection.

Detailed explanation-3: -Because optimal functioning of fibroblasts and inflammatory cells is paramount to the healing process, glutamine is also a necessary component of the process of tissue repair5.

Detailed explanation-4: -Wound healing is divided into four overlapping states: 1) homeostasis, 2) inflammatory, 3) proliferative, and 4) remodeling.