PATHOLOGY

Detailed explanation-1: -Remodelling. Remodelling is the final phase of the healing process in which the granulation tissue matures into scar and tissue tensile strength is increased (Figure 23.5).

Detailed explanation-2: -Phase 4: Maturation (strengthening) Even after your wound looks closed and repaired, it’s still healing – this is called the Maturation phase. During this phase the new tissue slowly gains strength and flexibility. You may also experience itching or tightness over the area at this time.

Detailed explanation-3: -The third phase of healing consists of remodeling, which begins two to three weeks after the onset of the lesion and can last for one year or more. The core aim of the remodeling stage is to achieve the maximum tensile strength through reorganization, degradation, and resynthesis of the extracellular matrix.

Detailed explanation-4: -Maturation Phase (Remodelling Stage) The collagen laid down during the proliferative phase, it is disorganized and the wound is thick. Collagen is remodelled into a more organized structure along lines of stress, thereby increasing the tensile strength of the healing tissues.

Detailed explanation-5: -Wound healing is classically divided into 4 stages: (A) hemostasis, (B) inflammation, (C) proliferation, and (D) remodeling. Each stage is characterized by key molecular and cellular events and is coordinated by a host of secreted factors that are recognized and released by the cells of the wounding response.