PATHOLOGY

Detailed explanation-1: -FIGURE 23.1. Phases of Normal Wound Healing. Cellular and molecular events during normal wound healing progress through four major, integrated, phases of haemostasis, inflammation, proliferation and remodelling.

Detailed explanation-2: -Wound healing is classically divided into 4 stages: (A) hemostasis, (B) inflammation, (C) proliferation, and (D) remodeling. Each stage is characterized by key molecular and cellular events and is coordinated by a host of secreted factors that are recognized and released by the cells of the wounding response.

Detailed explanation-3: -Wound healing is divided into four overlapping states: 1) homeostasis, 2) inflammatory, 3) proliferative, and 4) remodeling.

Detailed explanation-4: -The complicated mechanism of wound healing occurs in four phases: hemostasis, inflammation, proliferation, and remodeling.

Detailed explanation-5: -Phase 4: Maturation Phase During the Maturation phase, the new tissue slowly gains strength and flexibility. Here, collagen fibers reorganize, the tissue remodels and matures and there is an overall increase in tensile strength (though maximum strength is limited to 80% of the pre-injured strength).