PATHOLOGY

Detailed explanation-1: -Proliferative phase The most important cell is the fibroblast. Fibroblasts peak approximately day 7 from injury and are responsible for initiating angiogenesis, epithelialization, and collagen formation.

Detailed explanation-2: -In the proliferation stage, your body creates scar tissue to repair your injury. This phase of healing starts within 24 – 48 hours, peaks at around 2 – 3 weeks after your injury and stops after around 4 – 6 months. This is the reason why you will still be experiencing symptoms a couple of weeks after your injury.

Detailed explanation-3: -In the proliferation phase, the provisional wound matrix formed during haemostasis is replaced by granulation tissue, consisting of a large amount of fibroblasts, granulocytes, macrophages, blood vessels, in complex with collagen bundles, which partially recovers the structure and function of the wounded skin [35].

Detailed explanation-4: -In the wound environment, collagens mediate several key steps such as platelet aggregation, inflammation modulation, angiogenesis, granulation tissue formation and re-epithelialization in a integrin signaling-dependent manner [31, 32, 39].