PATHOLOGY

Detailed explanation-1: -Bone resorption is the process by which the bones are absorbed and broken down by the body. Osteoclast cells are responsible for the breakdown of bone minerals thus releasing calcium and phosphorous into the bloodstream.

Detailed explanation-2: -Osteoclasts are giant multinuclear bone cells of hematopoietic origin responsible for dissolution and absorption of bone.

Detailed explanation-3: -Bone tissue is continuously remodeled through the concerted actions of bone cells, which include bone resorption by osteoclasts and bone formation by osteoblasts, whereas osteocytes act as mechanosensors and orchestrators of the bone remodeling process.

Detailed explanation-4: -Bone resorption is the unique function of the osteoclast, and anti-osteoporosis therapy to date has targeted this cell. The osteoclast is a specialized macrophage polykaryon whose differentiation is principally regulated by macrophage colony-stimulating factor, RANK ligand, and osteoprotegerin.