PATHOLOGY

Detailed explanation-1: -During the maturation and remodeling processes, the majority of blood vessels, fibroblasts, and inflammatory cells disappear from the wound area due to emigration processes, apoptosis, or other unknown mechanisms of cell death. This fact leads to the formation of a scar with a reduced number of cells.

Detailed explanation-2: -Wound healing is classically divided into 4 stages: (A) hemostasis, (B) inflammation, (C) proliferation, and (D) remodeling. Each stage is characterized by key molecular and cellular events and is coordinated by a host of secreted factors that are recognized and released by the cells of the wounding response.

Detailed explanation-3: -Maturation is the final phase and occurs once the wound has closed. This phase involves remodelling of collagen from type III to type I. Cellular activity reduces and the number of blood vessels in the wounded area regress and decrease.

Detailed explanation-4: -Inflammatory phase – This phase begins at the time of injury and lasts up to four days. Proliferative phase – This phase begins about three days after injury and overlaps with the inflammatory phase. Remodeling phase – This phase can continue for six months to one year after injury.