PATHOLOGY

Detailed explanation-1: -Myofibroblasts produce a wound matrix enriched in fibronectin and hyaluronan. As wound healing continues, myofibroblasts are replaced by fibroblasts that lay down a collagenous matrix of scar tissue.

Detailed explanation-2: -By days 5 through 7, the fibroblasts have started to lay down new collagen and glycosaminoglycans. These proteoglycans form the core of the wound and help stabilize the wound. Then, reepithelialization starts to occur with the migration of cells from the wound periphery and adjacent edges.

Detailed explanation-3: -Once the fibroblasts have migrated into the matrix they again change their morphology, settle down and begin to proliferate and to synthesize granulation tissue components including collagen, elastin and proteoglycans. Fibroblasts attach to the cables of the provisional fibrin matrix and begin to produce collagen.

Detailed explanation-4: -Fibroblastic (Repair) Phase: 4 days – up to 6 weeks During this phase collagen fibers are set down in the damaged area in the form of scar tissue. This type of tissue is less tensile and weaker making it susceptible to damage if overloaded.

Detailed explanation-5: -Collagen III is the first to be synthesized in the early stages of wound healing and is replaced by collagen I, the dominant skin collagen. The initial random deposition of collagen during the granulation tissue formation is further enhanced by lysyl oxidase enzyme-induced covalent cross-linking.