PATHOLOGY

Detailed explanation-1: -Local complications include delayed and non-healing of the wound, cellulitis, abscess formation, osteomyelitis as well as further wound breakdown. Systemic complications include bacteremia with the possibility of distant hematogenous spread and sepsis.

Detailed explanation-2: -Chemotherapy also affects and destroys patients’ immune system, further hindering wound healing, and puts patients at risk of wound infections [23]. Chemotherapeutics such as cyclophosphamide and cisplatin block the cell cycle by alkylating DNA nucleotides, thus complicating wound healing.

Detailed explanation-3: -An ulcerating cancer wound is when a cancer that is growing under the skin breaks through the skin and creates a wound. Doctors sometimes call them fungating cancer wounds. When the cancer grows, it blocks and damages tiny blood vessels. This can reduce the supply of oxygen to the area.

Detailed explanation-4: -Infection. The most common cause of delayed healing in chronic wounds is infection. Osteomyelitis. Tissue Necrosis and Gangrene. Periwound Dermatitis. Edema and Periwound Edema. Hematomas. Dehiscence. 28-Mar-2018