PATHOLOGY

Detailed explanation-1: -Basal epithelial cells proliferate and migrate over the granulation tissue to close the wound surface. Remodelling – fibroblast and capillary density decreases, and initial scar tissue is removed and replaced by ECM that is more similar to normal skin.

Detailed explanation-2: -The fibrous tissue is laid down by fibroblasts, which migrate to the injured area, proliferate and secrete collagen under the influence of numerous growth factors and cytokines.

Detailed explanation-3: -By days 5 through 7, the fibroblasts have started to lay down new collagen and glycosaminoglycans. These proteoglycans form the core of the wound and help stabilize the wound. Then, reepithelialization starts to occur with the migration of cells from the wound periphery and adjacent edges.

Detailed explanation-4: -Fibroblastic (Repair) Phase: 4 days – up to 6 weeks During this phase collagen fibers are set down in the damaged area in the form of scar tissue. This type of tissue is less tensile and weaker making it susceptible to damage if overloaded.

Detailed explanation-5: -Proliferative Stage This stage is highly cellular with the primary cell types, including fibroblasts, keratinocytes, and endothelial cells. Fibroblasts function to synthesize collagen and the extracellular matrix.