PATHOLOGY

Detailed explanation-1: -Regeneration refers to a type of healing in which new growth completely restores portions of damaged tissue to their normal state.

Detailed explanation-2: -In gap repair, healing begins as blood vessels and loose connective tissue fill the wound. After 2 weeks pluripotent mesenchymal cells derived from the bone marrow arrive at the site of injury and differentiate into bone-producing cells called osteoblasts.

Detailed explanation-3: -During the healing process, damaged cells capable of proliferation regenerate. Different types of cells vary in their ability to regenerate. Some cells, such as epithelial cells, regenerate easily, whereas others, such as liver cells, do not normally proliferate but can be stimulated to do so after damage has occurred.

Detailed explanation-4: -Thus, the healing process begins with hemostasis, platelet deposition at the site of injury, and interactions of soluble mediators and growth factors with the extracellular matrix to set the stage for subsequent healing events.