PATHOLOGY

Detailed explanation-1: -Collagen type I (Col-I) is unique due to its high biocompatibility in human tissue. Despite its availability from various sources, Col-I naturally mimics the extracellular matrix (ECM) and generally makes up the larger protein component (90%) in vasculature, skin, tendon bone, and other tissue.

Detailed explanation-2: -The main five types of collagen and what they do are: Type I. This type makes up 90% of your body’s collagen. Type I is densely packed and used to provide structure to your skin, bones, tendons and ligaments.

Detailed explanation-3: -Collagen I is found in virtually all extracellular matrices, including bone, skin, and tendons while collagen III also is an important component of blood vessels and hollow organs (1). Mutations in collagen type III underlie the vascular type of EDS (EDS type IV).

Detailed explanation-4: -Most collagen fibrils are comprised of several collagen types and are called heterotypic. Collagen fibrils are made of collagens II, XI, and IX or of collagens II and III (Wu et al. 2010) in cartilage, of collagens I and III in skin, and of collagens I and V in cornea (Bruckner et al.

Detailed explanation-5: -Collagen type I (native) is a protein found in skin, tendons, ligaments, and bone. Most collagen type I in supplements comes from cows. Collagen type I plays a major role in wound healing. But it’s not clear if taking collagen type I by mouth has any beneficial effects.