PATHOLOGY

Detailed explanation-1: -The macrophage has been suggested to be responsible for the connective tissue cell proliferation that accompanies most chronic inflammatory responses. One of the secretory products of activated macrophages is MDGF, a growth factor (or factors) for fibroblasts, 3T3 cells, smooth muscle, and vascular endothelium.

Detailed explanation-2: -In addition, macrophages produce reactive oxygen species, such as nitric oxide, that can kill phagocytosed bacteria. The heterogeneous nature of these cells may not solely be the result of their differentiation process, but it is likely to be inherited from their monocyte precursors.

Detailed explanation-3: -Fibroblast growth factors (FGF) are a family of cell signalling proteins produced by macrophages; they are involved in a wide variety of processes, most notably as crucial elements for normal development in animal cells.

Detailed explanation-4: -Macrophages Produce TGF--Induced (-ig-h3) following Ingestion of Apoptotic Cells and Regulate MMP14 Levels and Collagen Turnover in Fibroblasts.

Detailed explanation-5: -Macrophages are innate immune cells present in every tissue and necessary for homeostasis. Macrophages sense and respond to pathogens and other environmental challenges and participate in tissue repair after injury.