PATHOLOGY

Detailed explanation-1: -The collagen laid down during the proliferative phase, it is disorganized and the wound is thick. Collagen is remodelled into a more organized structure along lines of stress, thereby increasing the tensile strength of the healing tissues. Fibroblasts secrete matrix metalloproteinases.

Detailed explanation-2: -In the proliferation phase, the provisional wound matrix formed during haemostasis is replaced by granulation tissue, consisting of a large amount of fibroblasts, granulocytes, macrophages, blood vessels, in complex with collagen bundles, which partially recovers the structure and function of the wounded skin [35].

Detailed explanation-3: -The proliferative phase is the third phase in the healing process and lasts 6-21 days. This phase is characterized by the presence of granulation tissue and ultimately epithelialization. Fibroblasts are a key cell in this phase.

Detailed explanation-4: -The Proliferative phase features three distinct stages: 1) filling the wound; 2) contraction of the wound margins; and 3) covering the wound (epithelialization). During the first stage, shiny, deep red granulation tissue fills the wound bed with connective tissue, and new blood vessels are formed.