PATHOLOGY

Detailed explanation-1: -Inflammation, the next stage of wound healing occurs within the first 24 hours after injury and can last for up to 2 weeks in normal wounds and significantly longer in chronic non-healing wounds (Figure 23.3).

Detailed explanation-2: -In the end of the inflammation, we can observe the apoptosis of the immune cells and the apoptotic cells cleared by macrophages. We thought that clearance by macrophages of cells apoptosis is a key point phenomenon associated with actively tissue formation from wound inflammation.

Detailed explanation-3: -The inflammatory response has four phases: inflammatory inducers (infection or tissue damage), inflammatory sensors (mast cells and macrophages), inflammatory mediators (cytokines, chemokines, etc.) and the tissues that are affected. Each phase has many options that are triggered based on the type pathogen introduced.

Detailed explanation-4: -Acute-swelling stage. Sub-acute – regenerative stage. Chronic – scar tissue maturation and remodelling stage.