PATHOLOGY

Detailed explanation-1: -Most of the removal of effete and damaged cells is performed by macrophages and neutrophils through phagocytosis, a complex phenomenon involving ingestion and degradation of the disposable particles.

Detailed explanation-2: -Phagocytosis can be divided into four main steps: (i) recognition of the target particle, (ii) signaling to activate the internalization machinery, (iii) phagosome formation, and (iv) phagolysosome maturation.

Detailed explanation-3: -phagocyte, type of cell that has the ability to ingest, and sometimes digest, foreign particles, such as bacteria, carbon, dust, or dye. It engulfs foreign bodies by extending its cytoplasm into pseudopods (cytoplasmic extensions like feet), surrounding the foreign particle and forming a vacuole.

Detailed explanation-4: -Phagocytosis is a cellular process for ingesting and eliminating particles larger than 0.5 m in diameter, including microorganisms, foreign substances, and apoptotic cells. Phagocytosis is found in many types of cells and it is, in consequence an essential process for tissue homeostasis.