PATHOLOGY

Detailed explanation-1: -Germinal center B cells may differentiate into memory B cells or plasma cells. Most of these B cells will become plasmablasts (or “immature plasma cells"), and eventually plasma cells, and begin producing large volumes of antibodies. Some B cells will undergo a process known as affinity maturation.

Detailed explanation-2: -B lymphocytes activated by T cells in secondary lymphoid organs mature into plasma cells after migration into the medullary cords of these organs, mucosal lamina propria or bone marrow.

Detailed explanation-3: -Follicular helper T Cells (Tfh). There, they induce the formation of germinal centers, the transformation of B Cells into plasma cells, the production of antibodies with different isotypes, and the production of memory B Cells (35).

Detailed explanation-4: -Results from a new study by Cobaleda and colleagues now show that, in contrast to the view that lineage commitment is a unidirectional and irreversible process, deletion of Pax5 in mature B cells allows their dedifferentiation into progenitor cells, which can then develop into functional T cells.

Detailed explanation-5: -T-cells. While B-cells produce antibodies to fight infection, T-cells protect people from getting infected by destroying cancerous and infected cells. B-cells are also far more likely than T-cells to mutate into a liquid cancer such as chronic lymphocytic leukemia (CLL) or B-cell lymphoma.