PATHOLOGY

Detailed explanation-1: -The Immune System Your immune system overreacts by producing antibodies called Immunoglobulin E (IgE). These antibodies travel to cells that release chemicals, causing an allergic reaction. This reaction usually causes symptoms in the nose, lungs, throat, sinuses, ears, lining of the stomach or on the skin.

Detailed explanation-2: -Histamine, which is stored mainly in mast cells and basophils, is a prominent contributor to allergic disease. Elevations in plasma or tissue histamine levels have been noted during anaphylaxis and experimental allergic responses of the skin, nose, and airways.

Detailed explanation-3: -Allergic rhinitis typically causes cold-like symptoms, such as sneezing, itchiness and a blocked or runny nose.

Detailed explanation-4: -Histamine dilates the small blood vessels of the nose and fluids leak out into the surrounding tissues, causing runny noses, watery eyes, itching, swelling and other allergy symptoms. Antibodies circulate in the blood stream, but localize in the tissues of the nose and in the skin.