PATHOLOGY MCQ
IMMUNE RESPONSE
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Question
[CLICK ON ANY CHOICE TO KNOW THE RIGHT ANSWER]
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Fibrin is converted to fibrinogen which then altersprothrombin into thrombin.
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Thrombin is converted to prothrombin which then altersfibrinogen into fibrin.
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Fibrinogen is converted to fibrin which then altersprothrombin into thrombin.
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Prothrombin is converted to thrombin which then altersfibrinogen into fibrin.
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Detailed explanation-1: -Once activated to factor Xa, it goes on to activate factor II (prothrombin) into factor IIa (thrombin). Also, factor Xa requires factor V as a cofactor to cleave prothrombin into thrombin. Factor IIa (thrombin) goes on to activate fibrinogen into fibrin.
Detailed explanation-2: -The coagulation process consists of the conversion of prothrombin to thrombin and of the subsequent action of thrombin on fibrinogen to produce fibrin. In the fibrinogen-fibrin conversion fibrinogen, already a high polymer of many amino acids is converted to an even higher polymeric form or coagulum, the fibrin clot.
Detailed explanation-3: -Prothrombin is transformed into thrombin by a clotting factor known as factor X or prothrombinase; thrombin then acts to transform fibrinogen, also present in plasma, into fibrin, which, in combination with platelets from the blood, forms a clot (a process called coagulation).
Detailed explanation-4: -During the initiation phase of coagulation, tissue factor–mediated factor VIIa is able to create small amounts of factor Xa, which then converts initial amounts of prothrombin (factor II) to thrombin (factor IIa).