PATHOLOGY

Detailed explanation-1: -The macrophages and neutrophils of the innate immune system provide a first line of defense against many common microorganisms and are essential for the control of common bacterial infections.

Detailed explanation-2: -Macrophages are first responders for the immune system. In this role, they have both effector functions for neutralizing pathogens and sentinel functions for alerting other immune cells of diverse pathologic threats, thereby initiating and coordinating a multipronged immune response.

Detailed explanation-3: -Polymorphonuclear neutrophils (PMNs) are the most abundant leukocytes in the circulation, and the first cellular responders to tissue injury and infection.

Detailed explanation-4: -The first-responder cells in question are neutrophils, the most abundant of all white blood cells whose job is to heal wounds and clear away infection.

Detailed explanation-5: -2 Despite the different etiologies of these injuries, the resultant immune response is surprisingly similar. Next, neutrophils, monocytes and mature macrophages are recruited within the first few hours of injury, with neutrophils usually considered as the first responders.