PATHOLOGY

Detailed explanation-1: -Autoimmune disease occurs when a specific adaptive immune response is mounted against self antigens. The normal consequence of an adaptive immune response against a foreign antigen is the clearance of the antigen from the body.

Detailed explanation-2: -When you have an autoimmune disorder, your immune system does not distinguish between healthy tissue and potentially harmful antigens. As a result, the body sets off a reaction that destroys normal tissues. The exact cause of autoimmune disorders is unknown.

Detailed explanation-3: -The ability to discriminate between self and nonself antigens is vital to the functioning of the immune system as a specific defense against invading microorganisms. Failure of the immune system to “tolerate” self tissues can result in pathological autoimmune states leading to debilitating illness and sometimes death.

Detailed explanation-4: -Autoimmunity is caused by the breakdown in self and nonself discrimination. Autoimmunity is not caused by the lost of discrimination of self by innate immunity since non-vertebrates do not develop autoimmune disease, as evolution has only selected germ-line system of discrimination of nonself pathogens.