PATHOLOGY

Detailed explanation-1: -One of the best-known chemical mediators released from cells during inflammation is histamine, which triggers vasodilation and increases vascular permeability. Stored in granules of circulating basophils and mast cells, histamine is released immediately when these cells are injured.

Detailed explanation-2: -Histamine is a vasoactive amine that plays an important role in the early acute inflammatory response. Histamine is stored in the granules of mast cells, basophils, platelets. This histamine is released from these cells by the stimuli inducing acute inflammation, anaphylatoxins, and histamine releasing factors.

Detailed explanation-3: -The beginning of the inflammatory phase is characterized by the release of proinflammatory molecules by the platelets, forming the hemostasis clot and damaged host cells.

Detailed explanation-4: -Acute inflammation starts after a specific injury that will cause soluble mediators like cytokines, acute phase proteins, and chemokines to promote the migration of neutrophils and macrophages to the area of inflammation.

Detailed explanation-5: -Injured tissue mast cells release histamine, causing the surrounding blood vessels to dilate and increase in permeability.