PATHOLOGY

Detailed explanation-1: -Differentiation of classically activated macrophages requires a priming signal in the form of IFN-gamma 7 via the IFN-gamma R. When the primed macrophage subsequently encounters an appropriate stimulus, such as bacterial LPS, it becomes classically activated.

Detailed explanation-2: -Therefore, human macrophages in addition to lymphoid cells contribute to the IFN- response, providing another link between the innate and acquired immune responses.