PATHOLOGY

Detailed explanation-1: -Tumor necrosis factor (TNF) is a multifunctional cytokine that plays important roles in diverse cellular events such as cell survival, proliferation, differentiation, and death.

Detailed explanation-2: -Tumour Necrosis Factor alpha (TNF alpha), is an inflammatory cytokine produced by macrophages/monocytes during acute inflammation and is responsible for a diverse range of signalling events within cells, leading to necrosis or apoptosis. The protein is also important for resistance to infection and cancers.

Detailed explanation-3: -Tumor necrosis factor (TNF, TNF-a, cachectin) is a pleiotropic pro-inflammatory cytokine that exerts multiple biologic effects. TNF was originally identified as an anti-tumor agent that induced necrotic cell death in sarcomas and other tumor types.

Detailed explanation-4: -Both tumor necrosis factor-alpha (TNF) and Interleukin-1 (IL-1) are cytokines required for activating the innate immune response, 1 mediating the recruitment, activation, and adherence of circulating phagocytic cells (macrophages and neutrophils), and terminating the innate immune response.

Detailed explanation-5: -Tumor necrosis factor alpha (TNF-) is a proinflammatory cytokine with an important role in the pathogenesis of several diseases. Its encoding gene is located in the short arm of chromosome 6 in the major histocompatibility complex class III region.