PATHOLOGY MCQ
INFLAMMATION
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Question
[CLICK ON ANY CHOICE TO KNOW THE RIGHT ANSWER]
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And
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No
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Either A or B
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None of the above
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Detailed explanation-1: -Interleukin-17 (IL-17, also known as IL-17A) is a key cytokine that links T cell activation to neutrophil mobilization and activation. As such, IL-17 can mediate protective innate immunity to pathogens or contribute to the pathogenesis of inflammatory diseases, such as psoriasis and rheumatoid arthritis.
Detailed explanation-2: -Interleukin-17 (IL-17) induces the production of granulocyte colony-stimulating factor (G-CSF) and chemokines such as CXCL1 and CXCL2 and is a cytokine that acts as an inflammation mediator.
Detailed explanation-3: -Tumor necrosis factor (TNF) and interleukin-6 (IL-6) are examples of pro-inflammatory cytokines. People with autoimmune conditions often have abnormally high levels of these cytokines.
Detailed explanation-4: -IL-17 and TH17 cells play important roles in the pathologies of autoimmune diseases. Monoclonal antibodies targeting IL-17 have demonstrated clinical benefits. Clinical trials of IL-17 inhibitors reported new onset inflammatory bowel disease. IL-17 can directly inhibit the development of TH1 cells. More items