PATHOLOGY

Detailed explanation-1: -Inflammation occurs in response to physical trauma, intense heat and irritating chemicals, as well as to infection by viruses and bacteria. The inflammatory response: (1) prevents the spread of damaging agents to nearby tissues (2) disposes of cell debris and pathogens and (3) sets the stage for the repair process.

Detailed explanation-2: -The process from inflammation to the wound healing is divided into three phases: (1) inflammation process, (2) tissue formation, and (3) tissue remodeling. The inflammation program includes cell produced related factors and immune cells infiltration.

Detailed explanation-3: -Neutrophils represent the most abundant inflammatory cells to infiltrate a new wound and function mainly to remove debris and prevent infection [22, 23].

Detailed explanation-4: -Although the process of healing is continuous, it may be arbitrarily divided into four phases: (i) coagulation and haemostasis; (ii) inflammation; (iii) proliferation; and (iv) wound remodelling with scar tissue formation.