PATHOLOGY

Detailed explanation-1: -Inflammation is the immune system’s response to harmful stimuli, such as pathogens, damaged cells, toxic compounds, or irradiation [1], and acts by removing injurious stimuli and initiating the healing process [2]. Inflammation is therefore a defense mechanism that is vital to health [3].

Detailed explanation-2: -The inflammatory response (inflammation) occurs when tissues are injured by bacteria, trauma, toxins, heat, or any other cause. The damaged cells release chemicals including histamine, bradykinin, and prostaglandins. These chemicals cause blood vessels to leak fluid into the tissues, causing swelling.

Detailed explanation-3: -It is now recognized that inflammation induced by microbial infection and tissue damage is an essential mechanism of innate immune response. Proper inflammatory responses provide broad spectrum protection against infections and orchestrate long-term adaptive immunity toward specific pathogens.

Detailed explanation-4: -The inflammatory response is a defense mechanism that evolved in higher organisms to protect them from infection and injury. Its purpose is to localize and eliminate the injurious agent and to remove damaged tissue components so that the body can begin to heal.