PATHOLOGY

Detailed explanation-1: -It effectively begins with fibroblast migration into the wound, a process initiated primarily by the PDGF that has been released by platelets and macrophages. [2] PDGF stimulates fibroblastic proliferation, chemotaxis, and collagenase production. Fibroblasts lay down structural proteins such as collagen [Table 1[7].

Detailed explanation-2: -Both fibroblasts and myofibroblasts play a critical role in wound healing by generating traction and contractile forces, respectively, to enhance wound contraction.

Detailed explanation-3: -Fibroblasts are critical in supporting normal wound healing, involved in key processes such as breaking down the fibrin clot, creating new extra cellular matrix (ECM) and collagen structures to support the other cells associated with effective wound healing, as well as contracting the wound.

Detailed explanation-4: -Fibroblasts’ most well-known biological role is the production of the rich ECM of connective tissues. Fibroblasts produce and secrete all components of the ECM, including the structural proteins, adhesive proteins, and a space-filling ground substance composed of glycosaminoglycans and proteoglycans.