PATHOLOGY

Detailed explanation-1: -The predominant cell of acute inflammation is the neutrophil. They are attracted to the site of injury by the presence of chemotaxins, the mediators released into the blood immediately after the insult.

Detailed explanation-2: -Neutrophils are normally the first responders to acute inflammation and contribute to the resolution of inflammation. However, in chronic inflammation, the role of neutrophils is less well understood and has been described as either beneficial or detrimental, causing tissue damage and enhancing the immune response.

Detailed explanation-3: -The signs of inflammation include loss of function, heat, pain, redness, and swelling. Inflammation is part of the body’s complex biological response to harmful stimuli, such as irritants, pathogens, and damaged cells.

Detailed explanation-4: -The first cells attracted to a site of injury are neutrophils, followed by monocytes, lymphocytes (natural killer cells [NK cells], T cells, and B cells), and mast cells [71–73].

Detailed explanation-5: -Neutrophils, the most abundant leukocyte, reach the inflammatory site in a cascade-like manner, leading to activation of specific effector functions, such as release of reactive oxygen species, degranulation, formation of neutrophil extracellular traps (NETs), and phagocytosis.