PATHOLOGY MCQ
INFLAMMATION
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Question
[CLICK ON ANY CHOICE TO KNOW THE RIGHT ANSWER]
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Is often seen with persistent stimuli
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Is exudate filled with activated macrophages fused together
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Is a nodular area with a central area of neutrophils
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Is a distinct mass formed from macrophage infiltration
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Detailed explanation-1: -The granuloma is an organized aggregate of macrophages surrounded by a cuff of B and T lymphocytes. Plasma cells and dendritic cells are also granuloma associated. Within the granuloma, macrophages differentiate into additional cell types including epithelioid macrophages, MGCs and foamy macrophages.
Detailed explanation-2: -The granulomatous inflammatory response is a special type of chronic inflammation characterised by often focal collections of macrophages, epithelioid cells and multinucleated giant cells.
Detailed explanation-3: -A granuloma is a small area of chronic inflammation, characterized by a collection of macrophages, typically accompanied by helper T-cells.
Detailed explanation-4: -Granulomatous inflammation is caused by a variety of conditions including infection, autoimmune, toxic, allergic, drug, and neoplastic conditions. The tissue reaction pattern narrows the pathologic and clinical differential diagnosis and subsequent clinical management.