PATHOLOGY

Detailed explanation-1: -Cell types in inflammatory responses The first cells attracted to a site of injury are neutrophils, followed by monocytes, lymphocytes (natural killer cells [NK cells], T cells, and B cells), and mast cells [71–73].

Detailed explanation-2: -Neutrophils are the first cells to reach the site of infection, attracted by chemotactic factors such as complement, with their predominant role being phagocytosis.

Detailed explanation-3: -Transendothelial migration (TEM), the step in the inflammatory response in which leukocytes actually cross the endothelial cells lining the blood vessels at the site of inflammation, is a critical point in the regulation of this response.

Detailed explanation-4: -Neutrophils comprise 50% to 70% of circulating leukocytes and represent the body’s initial line of defense. They are involved in the acute inflammatory response to bacterial infection and removal of the bacteria by phagocytosis. They are also the most numerous cells to arrive at the site of injury or infection.