PATHOLOGY

Detailed explanation-1: -Excessive deposition of extracellular matrix gradually leads to the formation of fibrosis (hypertrophic scar) with loss of skin function.

Detailed explanation-2: -Remodelling is the final phase of the healing process in which the granulation tissue matures into scar and tissue tensile strength is increased (Figure 23.5).

Detailed explanation-3: -The extracellular matrix (ECM) is a critical structural component of any tissue, including the integument. Damage to the ECM through an acute or chronic source can lead to a series of healing events, coined the “wound healing cascade”.

Detailed explanation-4: -Wound healing, as a normal biological process in the human body, is achieved through four precisely and highly programmed phases: hemostasis, inflammation, proliferation, and remodeling. For a wound to heal successfully, all four phases must occur in the proper sequence and time frame.

Detailed explanation-5: -Collagen fiber is the major protein secreted by fibroblast, composed of extracellular matrix to replace wound tissue strength and function. Collagen fibers deposition was significant on 8–10 days after injury.