PATHOLOGY MCQ
INFLAMMATION
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Question
[CLICK ON ANY CHOICE TO KNOW THE RIGHT ANSWER]
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Which of the following prevents clotting during an inflammatory response?
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heparin
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neutrophils
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complement protein
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histamine
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Explanation:
Detailed explanation-1: -Heparin, used clinically as an anticoagulant, also has anti-inflammatory properties.
Detailed explanation-2: -If an appropriate concentration of heparin is added to whole blood the clotting time is prolonged, due presumably to the inactivation of C.F. by heparin: “available” heparin disappears during clotting and none is found in the serum.
Detailed explanation-3: -Heparins bind to antithrombin (AT) and induce a conformational change that makes AT an efficient inactivator of coagulation factors. Unfractionated heparin inhibits thrombin (factor IIa) by forming a ternary complex.
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