PATHOLOGY

Detailed explanation-1: -Bradykinin is among the major pain mediators during inflammation. Peripherally produced bradykinin alters the electrical functions of nociceptor sensory neurons that are the forefront initiators of the ascending signals of the sensory neural pathway for pain perception.

Detailed explanation-2: -The activation of the kinin system-bradykinin is particularly important in blood pressure regulation and in inflammatory reactions, through bradykinin ability to elevate vascular permeability and to cause vasodilatation in some arteries and veins.

Detailed explanation-3: -Bradykinin is a linear nonapeptide messenger belonging to the kinin group of proteins, with amino acid sequence RPPGFSPFR. Enzymatically produced from kallidin in the blood, it is a powerful vasodilator that causes smooth muscle contraction, and may mediate inflammation.

Detailed explanation-4: -Bradykinin, an inflammatory mediator, sensitizes nociceptor peripheral terminals reducing pain threshold.