PATHOLOGY

Detailed explanation-1: -The human pancreas secretes an impressive amount of sodium-bicarbonate–rich fluid with each meal. The majority of fluid and bicarbonate in pancreatic juice arises from the pancreatic duct cells, although they comprise only 5% of the pancreatic mass.

Detailed explanation-2: -Gastric acid stimulates secretin release, allowing movement into the duodenal lumen. Secretin causes an increase in pancreatic and biliary bicarbonate secretion and a decrease in gastric H+ secretion. Secretin stimulates the secretion of bicarbonate-rich pancreatic fluid.

Detailed explanation-3: -The human exocrine pancreas secretes 1-2 liters of pancreatic juice per day. When stimulated, the pancreas secretes alkaline pancreatic juice containing copious amounts of bicarbonate (HCO3-) (23, 74). HCO3-plays essential roles in the digestive system.