PATHOLOGY

Detailed explanation-1: -Irreversible responses of cell injury refer to changes that lead to a new equilibrium with the environment. Types of irreversible responses include: interruption of membrane integrity; hydrolysis of phospholipids, proteins and nucleic acids; and necrosis, where organelles undergo a sequence of changes.

Detailed explanation-2: -The different ways by which irreversible cell injury may occur are many. One such example is radiation that causes lipid peroxidation, or the breakdown of lipid-based cellular structures due to oxidation. Regardless of cause, cells may undergo necrosis, or cell death, as a result of an irreversible injury.

Detailed explanation-3: -When cells are injured, one of two patterns will generally result: reversible cell injury leading to adaptation of the cells and tissue, or irreversible cell injury leading to cell death and tissue damage.