IMMUNOLOGY

Detailed explanation-1: -There are also examples of viral proteins binding to autoantigens. For example, p53 has been described as an autoantigen in several autoimmune diseases, including lupus and scleroderma (82-84). p53 is a target of many viral proteins, including SV40 large T antigen (85), and HPV16/18 E6 proteins (86).

Detailed explanation-2: -Autoantigens. Autoantigens are the result of mutation, neoantigen formation, or exposure of previously hidden self-antigens. Genes producing self-proteins can mutate and create a new immunogenic protein called neoantigen. Viral infections and drugs can create neoantigens that stimulate an immune response.