IMMUNOLOGY

Detailed explanation-1: -In humans, pDCs, monocytes, and other myeloid cells also produce type I IFN after stimulation of the TLR8-MyD88-IRF7 pathway by viral single-stranded RNA (ssRNA) (33, 34).

Detailed explanation-2: -Human plasmacytoid dendritic cells (pDCs) were initially described 20 years ago by the Liu and Colonna groups. 1, 2 pDCs are continuously generated from haematopoietic stem cells in the bone marrow (BM) via both myeloid and lymphoid precursors.

Detailed explanation-3: -Although most cells in the body are thought to be able to produce type I IFN, plasmacytoid DCs (pDCs) have been termed the natural “IFN producing cells” due to their unique molecular adaptations to nucleic acid sensing and ability to produce high amounts of type I IFN.

Detailed explanation-4: -Type 1 interferons, such as IFN-, are produced in large quantities by activated plasmacytoid dendritic cells (pDCs), and are particularly important in resistance to virus infections.