ANTIGENS
ANTIGENS AND IMMUNOGENICITY
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Question
[CLICK ON ANY CHOICE TO KNOW THE RIGHT ANSWER]
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stimulate other immune system cells to respond to the antigen.
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stimulate macrophages to respond to the antigen.
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stimulate cell destruction by macrophages.
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stimulate cell destruction by activated T-cells.
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Detailed explanation-1: -An effector cytotoxic T cell kills a virus-infected cell when it recognizes fragments of viral protein bound to class I MHC proteins on the surface of the infected cell.
Detailed explanation-2: -MHC class I molecules are expressed on the cell surface of all nucleated cells and present peptide fragments derived from intracellular proteins. These peptides are normally derived from the cell’s own ‘house-keeping’ proteins but in a virally infected cell, peptides derived from viral proteins may also be presented.
Detailed explanation-3: -Macrophages can process and present exogenous antigens on major histocompatibility complex (MHC) class I molecules through an alternative mechanism involving the internalization of antigens and the secretion of peptides loading MHC class I molecules at the cell surface.