ANTIGENS
ANTIGENS AND IMMUNOGENICITY
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Question
[CLICK ON ANY CHOICE TO KNOW THE RIGHT ANSWER]
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MHC Class I molecule
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MHC Class II molecule
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MHC Class III molecule
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None of the above
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Detailed explanation-1: -MHC class III genes are located on chromosome 6 (6p21. 3) in humans. It covers 700 kb and contains 61 genes. The gene cluster is the most gene-dense region of the human genome.
Detailed explanation-2: -A non classical MHC-II molecule (HLA-DO and HLA-DM) catalyses the exchange of part of the CD74 (CLIP peptide) with the peptide antigen. Peptide-MHC-II complexes (pMHC-II) are transported to the plasma membrane and the processed antigen is presented to the helper T cells in the lymph nodes.
Detailed explanation-3: -The major histocompatibility (MHC) class I antigen presentation pathway plays an important role in alerting the immune system to virally infected cells. MHC class I molecules are expressed on the cell surface of all nucleated cells and present peptide fragments derived from intracellular proteins.