IMMUNOLOGY

Detailed explanation-1: -In order for the TCR to bind to the class I MHC molecule, the former must be accompanied by a glycoprotein called CD8, which binds to the constant portion of the class I MHC molecule. Therefore, these T cells are called CD8+ T cells.

Detailed explanation-2: -Cytotoxic T cells (TC) express CD8, which recognizes class I MHC proteins, whereas helper T cells (TH) express CD4, which recognizes class II MHC proteins.

Detailed explanation-3: -It is well established that major histocompatibility complex (MHC) class I and class II molecules are recognized by CD8+ and CD4+ T lymphocytes, respectively.

Detailed explanation-4: -To be recognized by a T cell, the antigen must bind a protein called the Major histocompatibility complex (MHC). Cytotoxic T cells recognize antigen bound to MHC protein type 1. [2] MHC not only aid in T cell activation, but it also has a vital role in the maturation of T cells in the thymus.