HYPERSENSITIVITY
CLASSICAL ALTERNATE AND LECTIN PATHWAYS
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Question
[CLICK ON ANY CHOICE TO KNOW THE RIGHT ANSWER]
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Antigen-antibody complexes are deposited in tissues and cause mast cell degranulation
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Type I
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Type II
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Type III
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Type IV
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Explanation:
Detailed explanation-1: -Complement activation leads to the recruitment of inflammatory cells (monocytes and neutrophils) that release lysosomal enzymes and free radicals at the site of immune complexes, causing tissue damage.
Detailed explanation-2: -This is the first major distinction between type II hypersensitivity reactions, which involve antibodies binding to antigens on cell surfaces, and type III hypersensitivity reactions, which involve immune complexes with soluble antigens.
Detailed explanation-3: -Examples of type III hypersensitivity reactions include drug-induced serum sickness, farmer’s lung and systemic lupus erythematosus.
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