HYPERSENSITIVITY
CLASSICAL ALTERNATE AND LECTIN PATHWAYS
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Question
[CLICK ON ANY CHOICE TO KNOW THE RIGHT ANSWER]
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IgG or IgM leads to complement activation and cell lysis
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Type I
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Type II
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Type III
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Type IV
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Explanation:
Detailed explanation-1: -It is well known that both IgG and IgM can activate complement via the classical pathway by binding of C1q to the Fc regions of these immunoglobulins. Recent advances have shown that also IgA is capable of activating the complement system.
Detailed explanation-2: -In contrast to IgG molecules that contain one Fc domain, pentameric IgM has five different Fc domains on the same molecule, facilitating rapid complement activation when a single IgM molecule recognizes a pathogen.
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