HYPERSENSITIVITY
CLASSICAL ALTERNATE AND LECTIN PATHWAYS
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Question
[CLICK ON ANY CHOICE TO KNOW THE RIGHT ANSWER]
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Secondary mediators (leukotrienes and prostaglandins produced by innate immune cells) are 1000x more potent than histamine at inducing bronchoconstriction and more potent stimulators of:
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vascular permeability
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mucous secretion
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asthma
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vascular constriction
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neuropathy
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Explanation:
Detailed explanation-1: -Leukotriene C was 600 to 9500 times more potent than histamine on a molar basis in producing an equivalent decrement in the maximum expiratory flow rate at 30 percent of vital capacity above residual volume.
Detailed explanation-2: -LTB4, which binds to the BLT1 receptor, is one of the most potent chemoattractants for many immune cells [25, 26]. Studies report expression of BLT1 by nonmyeloid cells such as vascular smooth muscle cells, endothelial cells, skeletal muscle satellite cells, and neural stem cells, albeit at low levels [27, 28, 29].
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