IMMUNOLOGY

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HYPERSENSITIVITY

CLASSICAL ALTERNATE AND LECTIN PATHWAYS

Question [CLICK ON ANY CHOICE TO KNOW THE RIGHT ANSWER]
The high-affinity IgE receptor FcRI linking receptors trigger ____ phosphorylation of ITAMs.
A
oxidative
B
Lyn-mediated
C
glucose
D
protein
Explanation: 

Detailed explanation-1: -The high-affinity IgE receptor, also known as FcRI, or Fc epsilon RI, is the high-affinity receptor for the Fc region of immunoglobulin E (IgE), an antibody isotype involved in the allergy disorder and parasites immunity. FcRI is a tetrameric receptor complex that binds Fc portion of the heavy chain of IgE.

Detailed explanation-2: -FcRI is multimeric and is a member of a family of related antigen/Fc receptors which have conserved structural features and similar roles in initiating intracellular signalling cascades. In humans, FcRI controls the activation of mast cells and basophils, and participates in IgE-mediated antigen presentation.

Detailed explanation-3: -Fc Receptors. There are two IgE receptors: FcRI is the high-affinity IgE receptor that is expressed by mast cells and basophils and by dendritic cells and Langerhans cells in the skin.

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