HYPERSENSITIVITY
CLASSICAL ALTERNATE AND LECTIN PATHWAYS
|
Question
[CLICK ON ANY CHOICE TO KNOW THE RIGHT ANSWER]
|
What do IL-4 and IL-13 stimulate?
|
|
TH2 responses to increase IgE production by B cells
|
|
|
TH1 responses to increase IgE production by B cells
|
|
|
TH2 responses to increase IgE production by T cells
|
|
|
TH1 responses to increase IgE production by T cells
|
Explanation:
Detailed explanation-1: -Mast Cells Produce IL-4 and IL-13 Mast cell cytokine secretion plays a pivotal role in the pathogenesis of allergic disease and inflammation [16].
Detailed explanation-2: -Both IL-4 and IL-13 induce IgE switching and IgE synthesis by human B cells activated by CD4+ T cells, Epstein-Barr virus transformation, or CD40 stimulation.
Detailed explanation-3: -Interleukin-4 (IL-4) is one such signal. Produced by TH2 cells, it collaborates with CD40 ligand in stimulating B cell proliferation and differentiation, and it promotes switching to IgE antibody production.
There is 1 question to complete.