HYPERSENSITIVITY
CYTOKINES
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Question
[CLICK ON ANY CHOICE TO KNOW THE RIGHT ANSWER]
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Which cytokine is made by macrophages and increases IFN-gamma production in NK cells?
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IL-1
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IL-4
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IL-10
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IL-12
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Explanation:
Detailed explanation-1: -IL-12 is produced primarily by DCs, macrophages, neutrophils, and B cells. IL-12 increases IFN- production from NK and T cells and enhances their lytic activity.
Detailed explanation-2: -These findings reveal that IL-12 can activate macrophages potently during intracellular infection, and this activating effect is mediated primarily through its effect on macrophage IFN-gamma release.
Detailed explanation-3: -Interleukin (IL)-12 is an interleukin produced primarily by antigen-presenting cells that play an essential role in the interaction between the innate and adaptive arms of immunity acting upon T and NK cells to generate cytotoxic lymphocytes.
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